Our core area of interest is the concept of the Learning Health System (LHS) which is a part of a growing field of ‘learning systems’ where knowledge acquisition and process improvement become at least semi-automated tasks of the human-cyber-social infrastructure. Thus, applications such as clinical trials, diagnostic support and epidemiological studies, are all redefined in terms of data and knowledge flows through the health system. Through our work, we are committed to improving the quality and safety of clinical care and the efficiency and effectiveness of the research it is based on.